The Journal of American Medical Science and Research

Current Understanding of Neuroinflammation and Neurodegeneration in Age-Related Neurological Disorders

1. Introduction Population aging has emerged as one of the most significant demographic trends of the twenty-first century. Advances in healthcare, nutrition, and living standards have substantially increased life expectancy

Synthesis, Characterization and Biological Evaluation of Some New Methylxanthine-Bearing Chalcone Derivatives as Antiproliferative agents

1. Introduction Chalcones are an important class of open-chain flavonoids chemically known as 1,3-diphenyl-2-propen-1-ones, in which two aromatic rings are connected through a three-carbon α,β-unsaturated carbonyl framework. Their characteristic structure contains

Effects of micro and nanoplastics on human health: A narrative review

Introduction Since 1862, when Alexander Parkes, an English metallurgist, created parkesine from cellulose, recognised as the first synthetic polymer in history, humanity has lived with a new material of high

1.0 Introduction Sickle cell anaemia (SCA) is one of the most common inherited haemoglobin disorders globally and remains a major public health challenge, particularly in sub-Saharan Africa, where the burden

D-Dimer level as a diagnostic marker in neonatal sepsis

Introduction Neonatal sepsis remains a formidable challenge in perinatal medicine, contributing significantly to neonatal morbidity and mortality worldwide. Its diagnosis is particularly difficult due to the non-specific and often

Clinician Perspectives on the use of Rabeprazole in the Management of Gastroesophageal reflux disease in Indian Settings

Introduction Gastroesophageal reflux disease (GERD) is one of the most prevalent gastrointestinal disorders globally and continues to impose a substantial clinical and public health burden. In 2021, an estimated 825.60

Association between Bacterial Virulence Factors and Host Immune Response: An Updated Review

1. Introduction Bacterial infections remain a significant cause of morbidity and mortality worldwide, particularly in developing regions where infectious diseases continue to impose a heavy healthcare burden. The pathogenesis and

Awareness, Knowledge and Perception of Sickle Cell Anaemia Among Adolescents in Selected Private Secondary Schools in Port Harcourt, Rivers State, Nigeria

GSK3β (rs334558) Promoter Polymorphism and Susceptibility to Breast Cancer: Case-Control Study in a South Indian Population with Comprehensive Statistical Analysis

Introduction Glycogen synthase kinase-3 beta (GSK3β; OMIM #605004) is one of those enzymes whose full significance in biology only became clear long after its initial discovery. Originally characterised as a

Journal of American Medical Science and research