Background: Drug-induced hypersensitivity reactions are significant from a therapeutic perspective. This case report highlights pantoprazole as a potential cause of hypersensitivity reactions.

Case Summary: A 55-year-old female presented to the outpatient department with lip swelling 40 minutes after ingesting pantoprazole.

Conclusion: Healthcare professionals should be aware of the risk of anaphylaxis, a potentially life-threatening reaction, associated with pantoprazole and exercise caution in its administration.