In Vitro Blood-Brain Barrier Models: Method Development, Validation And Application In CNS Drug Permeability Assessment
Introduction The blood-brain barrier (BBB) represents one of the most restrictive biological interfaces in the human body, functioning as a selective gatekeeper that maintains central nervous system (CNS) homeostasis by regulating molecular transport between systemic circulation and brain parenchyma [1]. This specialized endothelial barrier poses significant challenges for pharmaceutical development, as it prevents approximately 98% … Read more